Leather backpacks are generally heavier than those made from materials like nylon, canvas, or polyester due to the density and durability of genuine leather. While this added weight can provide better structure and longevity, it may also be a factor for those seeking a lightweight option. However, modern designs and softer leather varieties help balance durability with comfort. When comparing materials, consider factors like intended use, carrying capacity, and personal comfort to find the perfect backpack for your needs.